RAF Typhoon FGR4s have conducted a mission with French aircraft in a combined operation against an hidden munitions depot in Syria employed by the IS group, according to the UK's MoD.
The site, pinpointed through intelligence, was believed to be storing arms and explosives, the statement said, and was located in mountains just above the historic site of Palmyra in Syria's central region.
"The RAF jets utilized precision-guided Paveway IV munitions to hit a series of entry passages leading to the site... initial indications are that the strike was effective," the ministry announced.
There was no evidence of any harm to civilians in the attack conducted Saturday night and every plane involved returned safely, the defence officials confirmed.
The British jets were backed up by a Voyager aerial refuelling aircraft.
IS - also known as Daesh - established militant control over parts of both Syria and Iraq until 2019.
"This strike shows our UK leadership, and determination to operate in unison with allied nations, to stamp out any revival of Daesh and their harmful and extremist ideologies in the Middle East," the British Defence Secretary the minister said.
UK warplanes have performed overwatch operations over Syrian airspace to "forestall any efforts to regroup" of the group subsequent to its military defeat at the Baghuz confrontation in the year 2019, the ministry said.
"I must thank all the members of British forces who took part in this operation for their expertise and their bravery," Healey said. "They were part of thousands of British troops deployed over the holidays. This mission, to remove terrorist threats who endanger our security, shows how our armed forces are ready to step up, all year round, protecting the UK within its borders and strong abroad."
In December, the American forces executed what it described as a "large-scale strike" on Islamic State objectives in Syria, subsequent to an attack resulted in the deaths of two US servicemembers and a local interpreter in the Palmyra area.
The United Nations reports Islamic State still boasts roughly 5-7 thousand combatants in Iraq and Syria.
